(*Corresponding Author, ^#Undergraduate Student, and ^†Equal Contribution)
A complete and updated list of publications can be found here.

Publications at Yale:

1. Perets, E. A.; Olesen, K. B.; Yan, E. C. Y.* "Chiral Sum Frequency Generation Spectroscopy Detects Double-Helix DNA at Interfaces" Langmuir, 38, 5765, 2022.
2. Konstantinovsky, D.; Perets, E. A.; Yan, E. C. Y.*; Hammes-Schiffer, S.* "Simulation of the Chiral Sum Frequency Generation Response of Supramolecular Structures Requires Vibrational Couplings" The Journal of Physical Chemistry B, 125, 12072, 2021.
3. Perets, E. A.^†; Konstantinovsky, D.^†; Fu, L.; Chen, J.; Wang, H.-F.; Hammes-Schiffer, S.*; Yan, E. C. Y.* "Mirror-image antiparallel β-sheets organize water molecules into superstructures of opposite chirality" Proceedings of the National Academy of Sciences, 117, 32902, 2020.

   Read the commentary: Pullanchery and Roke. "Handy water: Chiral superstructures around peptide β-sheets".

4. Perets, E. A.; Chabeda, D.^#; Gong, A. Z.^#; Huang, X.; Fung, T. S.; Ng, K. Y.; Bathgate, M.*; Yan, E. C. Y.* "Impact of the Emergency Transition to Remote Teaching on Student Engagement in a Non-STEM Undergraduate Chemistry Course in the Time of COVID-19" The Journal of Chemical Education, 97, 2439, 2020.
5. Perets, E. A.^†; Videla, P. E.^†; Yan, E. C. Y.*; Batista, V. S.* "Chiral Inversion of Amino Acids in Anti-Parallel β-sheets Probed by Vibrational Sum Frequency Generation Spectroscopy" The Journal of Physical Chemistry B, 123, 5769, 2019.
6. Perets, E. A.; Yan, E. C. Y.* "Chiral Water Superstructures Around Anti-Parallel β-sheets Observed by Chiral Vibrational Sum Frequency Generation Spectroscopy" The Journal of Physical Chemistry Letters, 10, 3395, 2019.
7. Liu, W.; Fu, L.; Wang, Z.; Sohrabpour, Z.; Li, X.; Liu, Y.; Wang, H.-F.; Yan, E. C. Y.* "Two dimensional crowding effects on protein folding at interfaces observed by chiral vibrational sum frequency generation spectroscopy" Physical Chemistry Chemical Physics, 20, 22421, 2018.
8. Culhane, K. J.; Belina, M. E.; Sims, J. N.; Cai, Y.; Liu, Y.; Wang, P. S. P.; Yan, E. C. Y.* "Parathyroid Hormone Senses Extracellular Calcium to Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor" ACS Chemical Biology, 13, 2347, 2018.
9. Kaufman, G.; Liu, W.; Williams, D. M.; Choo, Y.; Gopinadhan, M.; Samudrala, N.; Sarfati, R.; Yan, E. C. Y.; Regan, L.; Osuji, C.* "Flat Drops, Elastic Sheets, and Microcapsules by Interfacial Assembly of a Bacterial Biofilm Protein, BslA" Langmuir, 33, 13590, 2017.
10. Szundi, I.; Funatogawa, C.; Guo, Y.; Yan, E. C. Y.; Kliger, D. S.* "Protein Sequence and Membrane Lipid Roles in the Acitivation Kinetics of Bovine and Human Rhodopsins" Biophysical Journal, 113, 1934, 2017.
11. Liu, W.; Li, S.; Wang, Z.; Yan, E. C. Y.*; Leblanc, R. M.* "Characterization of surface-active biofilm protein BslA in self-assembling monolayer at the air-water interface" Langmuir, 33, 7548, 2017.
12. Cai, Y.; Liu, Y.; Culhane, K.J.; DeVree, B. T.; Yang, Y.; Sunahara, R. K.; Yan, E. C. Y.* "Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor" PLOS ONE, 12, e0179568, 2017.
13. Perets, E. A.; Yan, E. C. Y.* "The H₂O Helix: The Chiral Water Superstructure Surrounding DNA" ACS Central Science, 3, 683, 2017.
14. Guo, Y.; Hendrickson, H. P.; Videla, P. E.; Chen, Y.-N.; Ho, J.; Sekharan, S.; Batista, V. S.; Tully, J. C.; Yan, E. C. Y.* "Probing the remarkable thermal kinetics of visual rhodopsin with E181Q and S186A mutants" The Journal of Chemical Physics, 146, 215104, 2017.
15. Serebryany, E.; Folta-Stogniew, E.; Liu, J.; Yan, E. C. Y.* "Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor" FEBS Letters, 590, 4308, 2016.
16. Schloss, A.^†; Liu, W.^†; Williams, D. M.^†; Kaufman, G.; Hendrickson, H. P.; Rudshteyn, B.; Fu, L.; Wang, H.; Batista, V. S.; Osuji, C.; Yan, E. C. Y.*; Regan, L.*; "Fabrication of Modularly Functionalizable Microcapsules Using Protein-Based Technologies" ACS Biomater. Sci. Eng., 2, 1856, 2016.
17. Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E. C. Y.*; Standfuss, J. "Structural role of the T94I rhodopsin mutation in congenital stationary night blindness" EMBO reports, 17, 1237, 2016.
18. Wang, Z.; Morales-Acosta, M. D.; Li, S.; Liu, W.; Kanai, T.; Liu, Y.; Chen, Y. N.; Walker, F. J.; Ahn, C.; Leblanc, R. M.; Yan, E. C. Y.* "A Narrow Amide I Vibrational Band Observed by Sum Frequency Generation Spectroscopy Reveals Highly Ordered Structures of a Biofilm Protein at the Air/Water Interface" Chem. Comm., 52, 2956, 2016.
19. Fu, L.; Wang, Z.; Batista, V. S.; Yan, E. C. Y.*"New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes" Journal of Diabetes Research, Article ID 612051, 2015.
20. Culhane, K. J.; Liu, Y.; Cai, Y.; Yan, E. C. Y.*"Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors" Front. Pharmacol., 6, 264, 2015.
21. Wang, Z.; Fu, L.; Ma, G.; Yan, E. C. Y.*"Broad-Bandwidth Chiral Sum Frequency Generation Spectroscopy for Probing the Kinetics of Proteins at Interfaces" Langmuir, 31, 11384, 2015.
22. Fu, L.*; Wang, Z.; Psciuk, T. B.; Xiao, D.; Batista, V. S.; Yan, E. C. Y.*"Characterization of Parallel β-Sheets at Interfaces by Chiral Sum Frequency Generation Spectroscopy" J. Phys. Chem. Lett. 6, 1310, 2015.
23. Liu, Y.^†; Cai, Y.^†; Liu, W.; Li, X. H.; Rhoades, E.; Yan, E. C. Y.*"Triblock Peptide-Linker-Lipid Molecular Design Improves Potency of Peptide Ligands Targeting Family B G Protein-Coupled Receptors" Chem. Comm. 51, 6157, 2015.
    
    
24. Yan, E. C. Y.*; Wang, Z.; Fu, L. "Proteins at Interfaces Probed by Chiral Sum Frequency Generation Spectroscopy" J. Phys. Chem. B 119, 2769, 2015.
25. Mooney, V.; Skharan, S.; Liu, J.; Guo, Y.; Batista, V. S.; Yan, E. C. Y.* "Kinetics of Thermal Activation of an Ultraviolet Cone Pigment" J. Am. Chem. Soc. 137, 307, 2015.
26. Guo, Y.; Skharan, S.; Liu, J.; Batista, V. S.; Tully, J. C.*; Yan, E. C. Y.* "Role of Unusual Temperature-Dependent Kinetics of Thermal Reactions of Rhodopsin in Vertebrate Dim-Light Vision" Proc. Natl. Acad. Sci. U.S.A. 108, 26111, 2014.
    
    
27. Fu, L.; Wang, Z.; Yan, E. C. Y.* "N-H Stretching Modes Around 3300 Wavenumber From Peptide Backbones Observed by Chiral Sum Frequency Generation Vibrational Spectroscopy" Chirality 22, 306, 2014.
    
    
28. Yan, E. C. Y.*; Fu, L.; Wang, Z.; Liu, W. "Biological Macromolecules at Interfaces Probed by Chiral Sum Frequency Generation Spectroscopy" Special Thematic Issue: Aqueous Interfaces, Chem. Rev. 114, 8471, 2014.
29. Sekharan, S.*; Mooney, V.; Rivalta, I.; Kazmi, M. A.; Neitz, M.; Neitz, J.; Sakmar, T. P.; Yan, E. C. Y.*, Batista, V. B.* "Spectral Tuning of Ultraviolet Cone Pigments: An Interhelical Lock Mechanism" J. Am. Chem. Soc. 135, 19064, 2013.
30. Liu, W.; Wang, Z.; Fu, L.; Leblanc, R. M.; Yan, E. C. Y.* "Lipid Compositions Modulate Fluidity and Stability of Bilayers: Characterization by Surface Pressure and Sum Frequency Generation Spectroscopy" Langmuir 29,15022, 2013.
31. Guo, Y.; Young, K.; Yan, E. C. Y.* Book Chapter: “Guided Inquiry and Project-Based Learning in Biophysical Spectroscopy” in Teaching Bioanalytical Chemistry , Edited by Harvey J. M. Hou, ACS Books, Chapter 13, p261-291, 2013.
    
    
32. Liu, M. Y.^#; Liu, J.; Mehrotra, D.^#; Liu, Y.; Guo, Y.; Baldera-Aguayo, P. A.; Mooney, V.; Nour, A. M.; Yan, E. C. Y.* “Thermal Stability of Rhodopsin and Progression of Retinitis Pigmentosa: A Comparison of S186W and D190N Rhodopsin Mutants” J. Biol. Chem. 288, 17698, 2013.
    
    
33. Wang, Z.; Fu, L.; Yan, E. C. Y.* "C–H Stretch for Probing Kinetics of Self-Assembly into Macromolecular Chiral Structures at Interfaces by Chiral Sum Frequency Generation Spectroscopy" Langmuir 29, 4077, 2013.
34. Fu, L.^†; Xiao, D. Q.^†; Wang, Z.; Batista, V. S.*; Yan, E. C. Y.* “Chiral Sum Frequency Generation for In Situ Probing Proton Exchange in Antiparallel β-Sheets at Interfaces” J. Am. Chem. Soc. 135, 3592, 2013.
35. Mitra, N.^†; Liu, Y.^†; Liu, J.; Serebryany, E.; Mooney, V.; DeVree, B. T.; Sunahara, R. K.; Yan, E. C. Y.* “Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs” ACS Chem. Biol. 8, 617, 2013.
36. Zhu, G. A.^#; Serebryany, E.^#; Yan, E. C. Y.* "Rational Design of Supramolecular Lipid/Detergent Assemblies for Purification of G Protein-Coupled Receptors" Invited Submission, Encyclopedia of Supramolecular Chemistry, 2012.
    
    
37. Mooney, V.; Szundi, I.; Lewis, J. W.; Yan, E. C. Y.*; Kliger, D. S.* "Schiff Base Protonation Changes in Siberian Hamster Ultraviolet Cone Pigment Photointermediates" Biochemistry 51, 2630, 2012.
38. You, Y. M.^†; Bloomfield, A.^†; Liu, J.; Fu, L.; Herzon, S.*; Yan, E. C. Y.* “Real-Time Kinetics of Surfactant Molecules Transfer between Emulsion Particles Probed by In Situ Second Harmonic Generation Spectroscopy” J. Am. Chem. Soc. 134, 4264, 2012.
39. Xiao, D. Q.^†; Fu, L.^†; Liu, J.; Batista, V. S.*; Yan, E. C. Y.* “Amphiphilic Adsorption of Human Islet Amyloid Polypeptide Aggregates to Lipid/Aqueous Interfaces” J. Mol. Biol. 421, 537, 2012.
40. Serebryany, E.^#; Zhu, G. A.^#; Yan, E. C. Y.* "Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors" Invited Review, BBA-Biomembrane 1818, 225, 2012.
41. Fu, L.; Wang, Z.; Yan, E. C. Y.* “Chiral Vibrational Structures of Proteins at Interfaces Probed by Sum Frequency Generation Spectroscopy” Invited Submission, Special Issue: Applications of Circular Dichroism, Int. J. Mol. Sci. 12, 9404, 2011.
42. Liu, J; Liu, M. Y.^#; Fu, L.; Zhu, G. A.^#; Yan, E. C. Y.* "Chemical Kinetic Analysis of Thermal Decay of Rhodopsin Reveals Unusual Energetics of Thermal Isomerization and Hydrolysis of Schiff Base" J. Biol. Chem. 286, 38408, 2011.
    
    
43. Liu, J.; Liu, M. Y.^#; Mooney, V.; Bhagat, A.; Nguyen, J.; Yan, E. C. Y.* "Thermal Properties of Rhodopsin: Insight into Molecular Mechanism of Dim-Light Vision"  J. Biol. Chem. 286, 27622, 2011.
    
    
44. Fu, L.; Liu, J.; Yan, E. C. Y.* “Chiral Sum Frequency Generation Spectroscopy for Characterizing Protein Secondary Structures at Interfaces” J. Am. Chem. Soc. 133, 8094, 2011.
45. Wu, W. T.; Mitra, N.; Yan, E. C. Y.; Zhou, S. Q.* "Multifunctional Hybrid Nanogel for Integration of Optical Glucose Sensing and Self-Regulated Insulin Release at Physiological pH" ACS Nano 4, 4831, 2010.
46. Fu, L.; Ma, G.; Yan, E. C. Y.* “In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Sum Frequency Generation” J. Am. Chem. Soc.132, 5405, 2010.
    
47. Durrell, A. C; Gary, H. B.; Hazari, N.*; Incarvito, C. D.; Liu, J.; Yan, E. C. Y. "Tris (hydroxypropyl) phosphine Oxide: A Chiral Three-Dimensional Material with Non-linear Optical Properties" Cryst. Growth Des.10, 1482, 2010.
    
    
48. Liu, J.; Liu, M. Y.^#; Nguyen,J. B.; Bhagat, A.; Mooney, V.; Yan, E. C. Y.* " Thermal Decay of Rhodopsin Involves both Thermal Isomerization of 11-cis Retinal in the Retinal Binding Site and Hydrolysis of Schiff Base."  J. Am. Chem. Soc. 131, 8750, 2009.
49. Ma, G; Liu, J.; Fu, L.; Yan, E. C. Y.* "Probing Water and Biomolecules at the Air/Water Interface with a Broad-Bandwidth Vibrational Sum Frequency Generation Spectrometer from 3800 to 900 cm^-1" Appl. Spectro. 63, 528. 2009.
    
    

Publications prior to Yale:

1. Ahuja, S.; Eilers, M.; Hirshfeld, A.; Yan, E. C. Y.; Ziliox, M.; Sakmar, T. P.; Sheves, M.; Smith, S. O.* “6-s-cis Conformation and Polar Binding Pocket of the Retinal Chromophore in the Photoactivated State of Rhodopsin” J. Am. Chem. Soc.131, 15160, 2009.
   
   
2. Ahuja, S.; Hornak, V.; Yan, E. C. Y.; Syrett, N.; Goncalves, J. A.; Hirshfeld, A.; Ziliox, M.; Sakmar, T. P.; Sheves, M.; Reeves, P.J.; Smith, S. O.* & Eilers, M. "Helix Movement is Coupled to Displacement of Extracellular Loop 2 in Rhodopsin Activation." Nat. Struct. Mol. Biol.16, 168. 2009.
   
   
3. Ye, S. X.; Köhrer, C.; Huber, T.; Kazmi, M.; Sachdev, P.; Yan, E. C. Y.; Bhagat, A.^#; RajBhandary, U. L.; Sakmar, T. P.* “Site-specific Incorporation of Keto Amino Acids Into Functional G Protein-Coupled Receptors Using Unnatural Amino Acid Mutagenesis” J. Biol. Chem. 283, 1525, 2008.
   
   
4. Yan, E. C. Y.*; Epps, J.; Lewis, J. W.; Szundi, I; Bhagat, A.; Sakmar, T. P.; Kliger, D. S.* “Photointermediates of the Rhodopsin S186A Mutant as a Probe of the Hydrogen Bond Network in the Chromophore Pocket and Counterion Switch” Invited Paper, J. Phy. Chem. C. 111, 8843, 2007.
   
   
5. Vogel, R.*; Siebert, F; Yan, E. C. Y.; Sakmar, T. P.; Hirshfeld, A.; Sheves, M.* “Modulating Rhodopsin Receptor Activation by Altering the pKa of the Retinal Schiff Base” J. Am. Chem. Soc. 128, 10503, 2006.
   
   
6. Ludeke, S; Beck, R.; Yan, E. C. Y.; Sakmar, T. P.; Siebert, F.; Vogel, R.* “The Role of Glu181 in the Photoactivation of Rhodopsin”  J. Mol. Biol.  353, 245, 2005.
   
   
7. Yan, E. C. Y.; Ganim, Z.^#; Kazmi, M. A.; Chang, B. S. W.; Sakmar, T. P.; Mathies, R. A. “Resonance Raman Analysis of the Mechanism of Energy Storage and Chromophore Distortion in the Primary Visual Photoproduct” Biochemistry 43, 10867, 2004.
   
   
8. Yan, E. C. Y.; Kazmi, M.A.; Ganim, Z.^#; Hou, J. M.; Pan, D. H.; Chang, B. S. W.; Sakmar, T. P.; Mathies, R. A  “Retinal counterion Switch in the Photoactivation of G Protein-Coupled Receptor Rhodopsin” Proc. Natl. Acad. Sci. U.S.A. 100, 9262, 2003.
   
   Commentary by Birge, R. R. and Knox, B. E. “Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin” Proc. Natl. Acad. Sci. U.S.A. 100, 9105, 2003.
   
   
9. Yan, E. C. Y.; Kazmi, M. A.; De, S.; Chang, B. S. W.; Seibert, C.; Marin, E. P.; Mathies, R. A.; Sakmar, T. P. “Function of Extracellular Loop 2 in Bovine Rhodopsin: Glutamic Acid 181 Modulates Stability and Wavelength Maximal Absorption of Metarhodopsin II” Biochemistry 41, 3620, 2002.
   
   
10. Shang, X. M.; Liu, Y.; Yan, E. C. Y.; Eisenthal, K. B. “Effect of Counterions on Molecular Transport across Liposome Bilayer: Probed by Second Harmonic Generation” J. Phys. Chem. B. 105, 12816, 2001.
    
    
11. Yan, E.C.Y.; Liu, Y.; Eisenthal, K.B. “In-situ Studies of Molecular Transfer between Colloidal Surfaces by Second Harmonic Generation” J. Phys. Chem. B. 105, 8531, 2001.
    
    
12. Liu, Y.; Yan, E. C. Y.; Zhao, X. L.; Eisenthal, K. B. “Surface Potential of Charged Liposomes Determined by Second Harmonic Generation” Langmuir 17, 2063, 2001.
    
    
13. Liu, Y.; Yan, E. C. Y.; Eisenthal, K. B. “Effect of Lipid Composition on Molecular Adsorption and Transport across Liposome Bilayers” Biophys. J. 80, 1004, 2001.
    
    
14. Yan, E. C. Y.; Eisenthal, K. B. “Effects of Cholesterol on Molecular Transport of Organic Cations across Liposome Bilayers Probed by Second Harmonic Generation” Biophys. J. 79, 898, 2000.
    
    
15. Yan, E. C. Y.; Eisenthal, K. B. “Rotational Dynamics of Anisotropic Particles Studied by Second Harmonic Generation” J. Phys. Chem. B. 104, 6686, 2000.
    
    
16. Yan, E. C. Y.; Eisenthal, K. B. “Probing the Interface of Microscopic Clay Particles in Aqueous Solution by Second Harmonic Generation” J. Phys. Chem. B. 103, 6056, 1999.
    
    
17. Yan, E. C. Y.; Liu, Y.; Eisenthal, K. B. “New Method for Determination of Surface Potential of Microscopic Particles by Second Harmonic Generation” J. Phys. Chem. B 102, 6331, 1998.
    
    
18. Wang, H. F.; Yan, E. C. Y.; Liu, Y.; Eisenthal, K.B. “Energetics and Population of Molecules at Microscopic Liquid and Solid Surfaces” J. Phys. Chem. 102, 4446, 1998. .
    
    
19. Wang, H. F.; Borguet, E.; Yan, E. C. Y.; Zhang, D.; Gutow, J.; Eisenthal, K. B. “Molecules at Liquid and Solid Surfaces” Langmuir 14, 1472, 1998.
    
    
20. Wang, H. F.; Yan, E. C. Y.; Borguet, E.; Eisenthal, K. B. “Second Harmonic Generation from the Surface of Centrosymmetric Particles in Bulk Solution” Chem. Phys. Letts. 259, 15, 1996.
    
    
21. Wu, C.; Yan, C. Y.^# “Studies of the Swelling and Drying Kinetics of Thin Gel Films by In-Situ Interferometry” Macromolecules 27, 4516, 1994.