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(*Corresponding Author, #Undergraduate Student, and †Equal Contribution)
A complete and updated list of publications can be found here.
Publications at Yale:
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Perets, E. A.†; Konstantinovsky, D.†; Fu, L.; Chen, J.; Wang, H.-F.; Hammes-Schiffer, S.*; Yan, E. C. Y.* "Mirror-image antiparallel β-sheets organize water molecules into superstructures of opposite chirality" Proceedings of the National Academy of Sciences, 117, 32902, 2020.
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Perets, E. A.; Chabeda, D.#; Gong, A. Z.#; Huang, X.; Fung, T. S.; Ng, K. Y.; Bathgate, M.*; Yan, E. C. Y.* "Impact of the Emergency Transition to Remote Teaching on Student Engagement in a Non-STEM Undergraduate Chemistry Course in the Time of COVID-19" The Journal of Chemical Education, 97, 2439, 2020.
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Liu, W.; Fu, L.; Wang, Z.; Sohrabpour, Z.; Li, X.; Liu, Y.; Wang, H.-F.; Yan, E. C. Y.* "Two dimensional crowding effects on protein folding at interfaces observed by chiral vibrational sum frequency generation spectroscopy" Physical Chemistry Chemical Physics, 20, 22421, 2018.
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Culhane, K. J.; Belina, M. E.; Sims, J. N.; Cai, Y.; Liu, Y.; Wang, P. S. P.; Yan, E. C. Y.* "Parathyroid Hormone Senses Extracellular Calcium to Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor" ACS Chemical Biology, 13, 2347, 2018.
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Kaufman, G.; Liu, W.; Williams, D. M.; Choo, Y.; Gopinadhan, M.; Samudrala, N.; Sarfati, R.; Yan, E. C. Y.; Regan, L.; Osuji, C.* "Flat Drops, Elastic Sheets, and Microcapsules by Interfacial Assembly of a Bacterial Biofilm Protein, BslA" Langmuir, 33, 13590, 2017.
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Cai, Y.; Liu, Y.; Culhane, K.J.; DeVree, B. T.; Yang, Y.; Sunahara, R. K.; Yan, E. C. Y.* "Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor" PLOS ONE, 12, e0179568, 2017.
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Guo, Y.; Hendrickson, H. P.; Videla, P. E.; Chen, Y.-N.; Ho, J.; Sekharan, S.; Batista, V. S.; Tully, J. C.; Yan, E. C. Y.* "Probing the remarkable thermal kinetics of visual rhodopsin with E181Q and S186A mutants" The Journal of Chemical Physics, 146, 215104, 2017.
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Schloss, A.†; Liu, W.†; Williams, D. M.†; Kaufman, G.; Hendrickson, H. P.; Rudshteyn, B.; Fu, L.; Wang, H.; Batista, V. S.; Osuji, C.; Yan, E. C. Y.*; Regan, L.*; "Fabrication of Modularly Functionalizable Microcapsules Using Protein-Based Technologies" ACS Biomater. Sci. Eng., 2, 1856, 2016.
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Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E. C. Y.*; Standfuss, J. "Structural role of the T94I rhodopsin mutation in congenital stationary night blindness" EMBO reports, 17, 1237, 2016.
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Wang, Z.; Morales-Acosta, M. D.; Li, S.; Liu, W.; Kanai, T.; Liu, Y.; Chen, Y. N.; Walker, F. J.; Ahn, C.; Leblanc, R. M.; Yan, E. C. Y.* "A Narrow Amide I Vibrational Band Observed by Sum Frequency Generation Spectroscopy Reveals Highly Ordered Structures of a Biofilm Protein at the Air/Water Interface" Chem. Comm., 52, 2956, 2016.
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- Fu, L.; Wang, Z.; Yan, E. C. Y.* "N-H Stretching Modes Around 3300 Wavenumber From Peptide Backbones Observed by Chiral Sum Frequency Generation Vibrational Spectroscopy" Chirality 22, 306, 2014.
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Sekharan, S.*; Mooney, V.; Rivalta, I.; Kazmi, M. A.; Neitz, M.; Neitz, J.; Sakmar, T. P.; Yan, E. C. Y.*, Batista, V. B.* "Spectral Tuning of Ultraviolet Cone Pigments: An Interhelical Lock Mechanism" J. Am. Chem. Soc. 135, 19064, 2013.
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Liu, M. Y.#; Liu, J.; Mehrotra, D.#; Liu, Y.; Guo, Y.; Baldera-Aguayo, P. A.; Mooney, V.; Nour, A. M.; Yan, E. C. Y.* “Thermal Stability of Rhodopsin and Progression of Retinitis Pigmentosa: A Comparison of S186W and D190N Rhodopsin Mutants” J. Biol. Chem. 288, 17698, 2013.
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Mitra, N.†; Liu, Y.†; Liu, J.; Serebryany, E.; Mooney, V.; DeVree, B. T.; Sunahara, R. K.; Yan, E. C. Y.* “Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs” ACS Chem. Biol. 8, 617, 2013.
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Publications prior to Yale:
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Ahuja, S.; Eilers, M.; Hirshfeld, A.; Yan, E. C. Y.; Ziliox, M.; Sakmar, T. P.; Sheves, M.; Smith, S. O.* “6-s-cis Conformation and Polar Binding Pocket of the Retinal Chromophore in the Photoactivated State of Rhodopsin” J. Am. Chem. Soc.131, 15160, 2009.
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Ahuja, S.; Hornak, V.; Yan, E. C. Y.; Syrett, N.; Goncalves, J. A.; Hirshfeld, A.; Ziliox, M.; Sakmar, T. P.; Sheves, M.; Reeves, P.J.; Smith, S. O.* & Eilers, M. "Helix Movement is Coupled to Displacement of Extracellular Loop 2 in Rhodopsin Activation." Nat. Struct. Mol. Biol.16, 168. 2009.
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Ye, S. X.; Köhrer, C.; Huber, T.; Kazmi, M.; Sachdev, P.; Yan, E. C. Y.; Bhagat, A.#; RajBhandary, U. L.; Sakmar, T. P.* “Site-specific Incorporation of Keto Amino Acids Into Functional G Protein-Coupled Receptors Using Unnatural Amino Acid Mutagenesis” J. Biol. Chem. 283, 1525, 2008.
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Yan, E. C. Y.*; Epps, J.; Lewis, J. W.; Szundi, I; Bhagat, A.; Sakmar, T. P.; Kliger, D. S.* “Photointermediates of the Rhodopsin S186A Mutant as a Probe of the Hydrogen Bond Network in the Chromophore Pocket and Counterion Switch” Invited Paper, J. Phy. Chem. C. 111, 8843, 2007.
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Yan, E. C. Y.; Kazmi, M.A.; Ganim, Z.#; Hou, J. M.; Pan, D. H.; Chang, B. S. W.; Sakmar, T. P.; Mathies, R. A “Retinal counterion Switch in the Photoactivation of G Protein-Coupled Receptor Rhodopsin” Proc. Natl. Acad. Sci. U.S.A. 100, 9262, 2003.
Commentary by Birge, R. R. and Knox, B. E. “Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin” Proc. Natl. Acad. Sci. U.S.A. 100, 9105, 2003.
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Yan, E. C. Y.; Kazmi, M. A.; De, S.; Chang, B. S. W.; Seibert, C.; Marin, E. P.; Mathies, R. A.; Sakmar, T. P. “Function of Extracellular Loop 2 in Bovine Rhodopsin: Glutamic Acid 181 Modulates Stability and Wavelength Maximal Absorption of Metarhodopsin II” Biochemistry 41, 3620, 2002.
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