2000

Lantry, L. E.; Zhang, Z.; Hu, D.; Yao, R.; Gao, F.; Crist, K. A.; Ohkanda, J.; Hamilton, A. D.; Sebti, S. M.; Kelloff, G. J.; Lubet, R. A.; You, M.
"Chemotherapeutic effect of the farnesyltransferase inhibitor FTI-276 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in A/J Mouse Lung"
Carcinogenesis 2000, 21, 113–116.
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Jiang, K.; Coppola, D.; Crespo, N. C.; Nicosia, S. V.; Hamilton, A. D.; Sebti, S. M.; Cheng, J. Q.
"Phosphatidylinositol 3-kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis"
Mol. Cell .Biol. 2000, 20, 139–148.
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Carloni, V.; Pinzani, M.; Giusti, S.; Romanelli, R. G.; Parola, M.; Bellomo, G.; Failli, P.; Hamilton, A. D.; Sebti, S. M.; Laffi, G.; Gentilini, P.
"Tyrosine Phosphorylation of Focal Point Adhesion Kinase by PDGF is Dependent on Ras in Human Hepatic Stellate Cells"
Hepatology 2000, 31, 131–140.
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Linton, B.; Goodman, M. S.; Hamilton, A. D.
"Nitronate Anion Recognition and Modulation of Ambident Reactivity by hydrogen bonding Receptors"
Chem. Eur. J. 2000, 6, 2449–2455.
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Linton, B. R.; Carr, A. J.; Orner, B. P.; Hamilton, A. D.
"A Versitile One-pot Synthesis fo 1,3-substituted Guanidines from Carbamoyl-isothiocyanates"
J. Org. Chem. 2000, 65, 1566–1568.
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Peczuh, M. W.; Hamilton, A. D.
"Peptide and Protein Recognition by Designed Molecules"
Chem. Rev. 2000, 100, 2479–2494.
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Melendez, R. E.; Carr, A. J.; Linton, B. R.; Hamilton, A. D.
"Controlling Hydrogen Bonding: From Molecular Recognition to Organogelation"
Struct. Bond. 2000, 96, 31–61.
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Kucich, U.; Rosenblum, J. C.; Shen, G.; Abrams, W. R.; Hamilton, A. D.; Sebti, S. M.; Rosenbloom, J.
"TGF-b Stimulation of Fibronectin Transcription in Cultured Human Lung Fibroblasts Requires Active Geranylgeranyltransferase I, Phosphatidylcholine-specific Phospholipase C, Protein Kinase C-d, and p38, but not Erk1/erk2"
Arch. Biochem. Biophys. 2000, 374, 313–324.
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Cohen-Jonathan, E.; Muschel, R. J.; McKenna, W. G.; Evans, S.; Cerniglia, G.; Mick, R.; Kusewitt, D.; Sebti, S. M.; Hamilton, A. D.; Oliff, A.; Kohl, N.; Gibbs, J. B.; Bernhard, E. J.
"Farnesyltransferase Inhibitors Potentiate the Antitumor Effects of Radiation on a Human Tumor Xenograft Expressing Activated HRas"
Radiat. Res. 2000, 154, 125–132.
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Boota, A.; Johnson, B. A.; Lee, K. I.; Blaskovich, M. A.; Hamilton, A. D.; Pitt, B.; Sebti, S. M.; Davies, P.
"Superoxide Production by Pulmonary Vascular Smooth Muscle Cells Requires Farnesylated and Geranylgeranylated Proteins"
Am. J. Physiol. 2000, 278, L329–L334.
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Zafar, A.; Geib, S. J.; Hamuro, Y.; Carr, A. J.; Hamilton, A. D.
"Hydrogen Bonding Control of Molecular Self-assembly: Aggregation Behavior of Acylaminopyridine-carboxylic Acid Derivatives in Solution and the Solid State"
Tetrahedron 2000, 56, 8419–8427.
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Adnane, J.; Bizouarn, F. A.; Chen, Z.; Munoz-Antonia, T.; Ohkanda, J.; Hamilton, A. D.: Sebti, S. M.
"Inhibition of Farnesyltransferase Increases TGFb Type II Receptor Expression and Enhances the Responsiveness ofHuman Cancer Cells to TGFb"
Oncogene 2000, 19, 5525–5533.
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Rosenbloom, J.; Saitta, B.; Gaidarova, S.; Sandorfi, N.; Rosenbloom, J. C.; Abrams, W. R.; Hamilton, A. D.; Sebti, S. M; Kucich, U.; Jimenez, S. A.
"Inhibition of Type I Collagen Gene Expression in Normal and Systemic Sclerosis Fibroblasts by a Specific Inhibitor of Geranylgeranyltransferase I"
Arthritis and Rheumatism 2000, 42, 1624–1632.
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Sebti, S. M.; Hamilton, A. D.
"Farnesyltransferase and Geranylgeranyltransferase I Inhibitors and Cancer Therapy: Lessons From Mechanistic andBench to Bedside Translational Studies"
Oncogene 2000, 19, 6584–6593.
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Sebti, S. M.; Hamilton, A. D.
"Inhibition of Rho GTPases using Protein Geranylgeranyltransferase I Inhibitors"
Methods in Enzymology 2000, 325, 381–388.


Salvatella, X.; Peczuh, M.; Gairi, M.; Jain, R.; Sanchez-Quesada, J.; de Mendoza, J.; Hamilton, A. D.; Giralt, E.
"Side Chain Length Dependent Thermodynamics of a-Helical Peptide Recognition"
Chem. Commun. 2000, 1399–1400.
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Blaskovich, M. A.; Lin, Q.; Delarue, F. L.; Sun, J.; Park, H. S.; Coppola, D.; Hamilton, A. D.; Sebti, S. M.
"Design of GFB-111 a Platelet-derived Growth Factor Binding Molecule with Anti-angiogenic and Anti-cancer Activity Against Human Tumors in Mice"
Nat. Biotechnol. 2000, 18, 1065–1070.
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Allal, C.; Favre, G.; Couderc, B.; Sixou, S.; Hamilton, A. D.; Sebti, S. M.; Pradines, A.
"RhoA geranylgeranylation or farnesylation is required for suppression of p21WAF, promotion of cell growth and transformation, cytoskeleton organization, but not for induction of SRE transcription"
J. Biol. Chem. 2000, 275, 31001–31008.
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Peczuh, M.; Orner, B.; Hamilton, A. D.
"Scratching the Surface: Recognition of Protein Exteriors by Designed Molecules"
Chemistry in Britain 2000, 43–45.


Ghosh, I.; Hamilton, A. D.; Regan, L.
"Antiparallel Leucine Zipper Directed Protein Reassembly: Application to the Green Fluorescent Protein"
J. Am. Chem. Soc. 2000, 122, 5658–5659.
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Jain, R.; Hamilton, A. D.
"Protein Surface Recognition by Synthetic Receptors Based on a Tetraphenylporphyrin Scaffold"
Org. Lett. 2000, 1721–1723.
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Estroff, L.; Hamilton, A. D.
"Effective Gelation of Water using a Series of Bis-urea Derivatives"
Angew. Chem., Int. Ed. 2000, 39, 3447–3450.
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Kotare, M. A.; Ohkanda, J.; Lockman, J. W.; Qian, Y.; Blaskovich, M. A.; Sebti, S. M.; Hamilton, A. D.
"Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase"
Tetrahedron 2000, 56, 9833-9841.
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Coxon, F. P.; Helfrich, M. H.; Van't Hof, R.; Sebti, S.; Ralston, S. H.; Hamilton, A. D.; Rogers, M. J.
"Protein Geranylgeranylation is rrequired for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298"
J. Bone and Mineral Res. 2000, 15, 1467–1476.


Sebti, S. M.; Hamilton, A. D.
"Farnesyltransferase Inhibitors: Important Bench to Bedside Issues"
Expert Opin. Invest. Drugs 2000, 9, 2767–2782.
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Wei, S.; Gilvary, D. L.; Corliss, B. C.; Sebti, S.; Sun, J.; Straus, D. B.; Leibson, P. J.; Trapani, J. A.; Hamilton, A. D.; Weber, M. J.; Djeu, J. Y.
"Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway"
J. Immunol. 2000, 165, 3811–3819.
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Sebti, S. M.; Hamilton, A. D.
"Design of Growth Factor Antagonists with Antiangiogenic and Antitumor Properties"
Oncogene 2000, 19, 6566–6573.
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