Faculty Yale

Sarah A. Slavoff

Assistant Professor of Chemistry
Member of the Chemical Biology Institute
Member of Yale faculty since 2014

E-mail: sarah.slavoff@yale.edu
Web site: http://slavofflab.yale.edu/

Research The Slavoff lab is interested in developing new tools to elucidate novel functions of RNA in cells, including non-canonical translation, RNA degradation in cytoplasmic granules, and RNA trafficking. We will utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, microscopy, chemical synthesis, and light- and small molecule-mediated control of biomolecular function.

Education
B.S. University of Maryland, College Park, 2005
Ph.D. Massachusetts Institute of Technology, 2010
NIH Ruth L. Kirchstein Postdoctoral Fellow, Harvard University, 2010-14

Honors
Whitaker Health Sciences Fund Graduate Fellowship, MIT, 2006
American Chemical Society Division of Organic Chemistry/Genentech Graduate Fellowship, 2008
NIH Ruth L. Kirchstein National Research Service Award Postdoctoral Fellowship, 2011-2014

Recent Publications
S.A. Slavoff, I. Chen, Y. A. Choi, A. Y. Ting. Expanding the substrate tolerance of biotin ligase through exploration of enzymes from diverse species. J. Am. Chem. Soc. 2008, 130, 1160-1162.

S.A. Slavoff, D. S. Liu, J. D. Cohen, A. Y. Ting. Imaging protein-protein interactions inside living cells via interaction-dependent fluorophore ligation. J. Am. Chem. Soc. 2011, 133, 19769–19776.

S.A. Slavoff, A. J. Mitchell, A. G. Schwaid, M. N. Cabili, J. Ma, J. Z. Levin, A. D. Karger, B. A. Budnik, J. L. Rinn, A. Saghatelian. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nat. Chem. Biol. 2013, 9, 59-64.

A. G. Schwaid, D. A. Shannon, J. Ma,S.A. Slavoff, J. Z. Levin, E. Weerapana, A. Saghatelian. Chemoproteomic discovery of cysteine-containing human sORFs. J. Am. Chem. Soc. 2013, 135, 16750-16753.

J. Ma, C. C. Ward, I. Jungreis,S.A. Slavoff, A. G. Schwaid, J. Neveu, B. A. Budnik, M. Kellis, A. Saghatelian. The discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. J. Proteome Res. 2014, 13, 1757–1765.

S.A. Slavoff, J. Heo, B. A. Budnik, L. Hanakahi, A. Saghatelian. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. J. Biol. Chem. 2014, 289, 10950-10957.

Sarah Slavoff

Research Interests