Timothy R. Newhouse

Assistant Professor of Chemistry
Member of Yale faculty, starting 2013

E-mail: timothy.newhouse@yale.edu
Web site: http://campuspress.yale.edu/newhousegroup/

Research Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge. Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs. New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures. Through detailed mechanistic study, such technologies can be developed.

The development of general construction reactions has broad utility in a range of fields that rely on the synthesis of small molecules and functional materials. One particular area that we focus on is the total chemical synthesis of frameworks that are known to elicit powerful neurological effects. These substances serve as chemical probes to study fundamental aspects of neurological function and to address neurological dysfunction.

B.A. Colby College, 2005
Ph.D. The Scripps Research Institute, 2010
Postdoctoral Fellow, Harvard University, 2010-2013

Bristol-Myers Squibb Postdoctoral Fellowship, 2010-2013
Bristol-Myers Squibb Graduate Fellowship, 2008
Wayne L. Smitih Inorganic Chemistry Award, 2004
Bradford P. Mundy Organic Chemistry Award, 2003

Recent Publications
T.R. Newhouse, X. Li, M.M. Blewett, C.M.C. Whitehead, & E.J. Corey. A Tetradentate Ligand for the Enantioselective Ti(IV)-Promoted Oxidation of Sulfides to Sulfoxides: Origin of Enantioselectivity. J. Am. Chem. Soc. 2012, 134, 17354–17357.

T. Newhouse & P.S. Baran. If C-H Bonds Could Talk. Angew. Chem. Int. Ed. 2011, 50, 3362–3374.

T. Newhouse, C.A. Lewis, K.J. Eastman, & P.S. Baran. Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole-Aniline Coupling: Psychotrimine and Kapakahines B and F. J. Am. Chem. Soc. 2010, 132, 7119–7137.

T. Newhouse, C.A. Lewis, & P.S. Baran. Enantiospecific Total Syntheses of Kapakahines B and F. J. Am. Chem. Soc. 2009, 131, 6360–6361.

T. Newhouse & P.S. Baran. Total Synthesis of (±)-Psychotrimine. J. Am. Chem. Soc. 2008, 130, 10886–10887.

Timothy Newhouse

Research Interests