Faculty Yale

Ziad Ganim

Assistant Professor of Chemistry
Member of Yale faculty since 2014

E-mail: ziad.ganim@yale.edu
Web site: http://ganim.yale.edu/

Research Our research group is interested in mechanistic studies of chemical reactions at the single molecule level. Single molecule force manipulation and optical detection have revolutionized biophysics by characterizing states and kinetics traditionally obscured in ensemble averages; the development of single molecule vibrational spectroscopies will provide the structural resolution necessary to extend these tools to study chemical processes such as bond formation and dissociation, charge transfer, and ligand exchange. We will apply an array of single molecule techniques to study how metalloproteins facilitate redox chemistry in their active sites and to study mechanistic heterogeneity during carbon-carbon bond formation in organometallic catalysts. New theoretical and computational methods will be developed to understand these new spectroscopies and model reaction pathways.

B.S. University of California, Berkeley, 2003
Ph.D. Massachusetts Institute of Technology, 2010
Postdoctoral Fellow, Technical University of Munich, 2010-2014

Alexander von Humboldt Postdoctoral Fellowship, 2010-2012
Poitras Predoctoral Fellowship, 2008-2009
MIT Chemistry Outstanding Teaching Award, 2004
University of California Departmental Citation in Chemistry, 2003

Recent Publications
Z. Ganim, H.S. Chung, A.W. Smith, L.P. DeFlores, K.C. Jones, & A. Tokmakoff. Amide I 2DIR Spectroscopy of Proteins. Acc. Chem. Res. 2008, 41, 432-441.

Z. Ganim. Single-Molecule Vibrational Spectroscopy Adds Structural Resolution to the Optical Trap. Biophys. J. 2013, 104, 4-5.

Z. Ganim, A. Tokmakoff, & A. Vaziri. Vibrational excitons in ionophores; Experimental probes for quantum coherence-assisted ion transport and selectivity in ion channels. New J. Phys. 2010, 13, 113030.

Z. Ganim, K.C. Jones, & A. Tokmakoff. Insulin dimer dissociation and unfolding revealed by amide I two-dimensional infrared spectroscopy. Phys. Chem. Chem. Phys. 2010, 12, 3579-3588.